Format

Send to

Choose Destination
J Cardiovasc Pharmacol Ther. 2018 Sep 13:1074248418798631. doi: 10.1177/1074248418798631. [Epub ahead of print]

Comparison of Efficacy between Ramipril and Carvedilol on Limiting the Expansion of Abdominal Aortic Aneurysm in Mouse Model.

Author information

1
1 Division of Cardiology, Cardiovascular Center, Hallym University, Chuncheon, South Korea.
2
2 Department of Medicine, The Graduate School of Yonsei University, Seoul, South Korea.
3
3 Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University, Seoul, South Korea.
4
4 Department of Pathology, Yonsei University, Seoul, South Korea.
5
5 Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, Seoul, South Korea.

Abstract

OBJECTIVE:

Abdominal aortic aneurysm (AAA) is a common condition that may be life-threatening when it is unrecognized. The aim of this study is to evaluate and compare the efficacy of ramipril and carvedilol on limiting AAA expansion in mouse model.

METHODS AND RESULTS:

A total of 36 experimental AAA mouse model was induced with the continuous infusion of angiotensin II (Ang II) in 20-week-old male apolipoprotein E-deficient mice. They were randomly divided into 3 treatment groups and fed orally for 8 weeks; saline alone, ramipril (2.5 mg/30g/d), or carvedilol (3.125 mg/30g/d), respectively. Aortic diameter (AD) was measured by micro-computed tomography, and the level of biomarkers of aortic tissue such as monocyte chemoattractant protein-1 (MCP-1) and tissue inhibitor matrix metalloproteinase-1 (TIMP-1) was evaluated. After treatment, AD of both ramipril and carvedilol group was smaller than in the saline group. The percentage change of AD in both ramipril and carvedilol groups was significantly smaller than that of the saline group. Pathologic examination revealed relatively well-preserved aortic walls in the ramipril group compared to the carvedilol and saline groups. The level of MCP-1 was markedly decreased in both the ramipril and carvedilol groups compared to the saline group. The level of TIMP-1 was higher in the carvedilol group when compared to either the saline or ramipril groups.

CONCLUSIONS:

Ramipril and carvedilol treatment shows similar efficacy in limiting AAA expansion in mouse model. Future clinical research would be warranted to validate these results.

KEYWORDS:

abdominal aortic aneurysm; carvedilol; mouse model; ramipril

PMID:
30213197
DOI:
10.1177/1074248418798631

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center