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Org Lett. 2018 Sep 21;20(18):5960-5963. doi: 10.1021/acs.orglett.8b02671. Epub 2018 Sep 13.

A Rhodium-Catalyzed [3 + 2] Annulation of General Aromatic Aldimines/Ketimines and N-Substituted Maleimides.

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Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering , Hefei University of Technology , Hefei , 230009 , China.


A new class of rhodium-catalyzed, C-H activation triggered [3 + 2] annulations of aromatic aldimines or ketimines and maleimides was reported in this study. A broad scope of general imines without electron-withdrawing groups were successfully activated and could effectively react with N-substituted maleimide to afford pericyclic, multichiral centered amines in good yields and with excellent diastereoselectivity.

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