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Quant Imaging Med Surg. 2018 Aug;8(7):667-672. doi: 10.21037/qims.2018.08.07.

The protocol for the Prospective Urban Rural Epidemiology China Action on Spine and Hip status study.

Author information

1
Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
2
Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China.
3
Medical Research & Biometrics Center, National Center for Cardiovascular Disease, Beijing 102300, China.
4
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
5
Department of Radiology, Nanjing University of Chinese Medicine Affiliated Wujin Hospital of Traditional Chinese Medicine, Changzhou 213161, China.
6
Department of Radiology, the 4th People's Hospital of Shenyang, Shenyang 110031, China.
7
Department of Prevention and Healthcare, Shenyang No. 242 Hospital, Shenyang 110034, China.
8
Department of Radiology, the People's Hospital of Dayi County, Chengdu 611330, China.
9
Department of Prevention and Healthcare, Dayi County Public Health Hospital, Chengdu 611330, China.
10
Department of Radiology, Taiyuan Central Hospital, Taiyuan 030009, China.
11
Balingqiao Community Health Service Center, Taiyuan 030013, China.
12
Department of Radiology, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
13
Nanchang County Center for Disease Control & Prevention, Nanchang 330200, China.
14
Department of Radiology, West China Second University Hospital of Sichuan University, Chengdu 610041, China.
15
General Practice Department, West China Hospital of Sichuan University, Chengdu 610041, China.
16
Department of Radiology, Xi'an Honghui Hospital, Xi'an 710054, China.
17
Department of Prevention and Healthcare, Hospital of Xidian University, Xi'an 710071, China.
18
Department of Radiology, Beijing Shijingshan Hospital, Beijing 100043, China.
19
Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
20
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210019, China.
21
Center of Orthopedics, the 309th Hospital of People's Liberation Army, Beijing 100091, China.
22
National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Abstract

The Prospective Urban Rural Epidemiology (PURE) China Action on Spine and Hip status (CASH) study focused on the prevalence of osteoporosis and spinal fracture in China. The aim of the PURE CASH study is to determine the prevalence of osteoporosis and spinal fracture, and explore the potential relationship between spinal fracture and bone mineral density (BMD). This study is a prospective large-scale population study with a community-based sampling and recruitment strategy. The aim is to determine the prevalence of osteoporosis and vertebral fracture in this population, to evaluate the association between vertebral fractures and BMD values, and to assess the prediction power of BMD for incident fractures. Participants in the PURE CASH study are all from the PURE study in China, recruited from 12 centers in 7 Chinese provinces. The inclusion criteria are that participants should be aged more than 40 years and able to give informed consent. Exclusion criteria are pregnant women, individuals with metal implants in the lumbar spine, use of medications or the existence of any disease or condition known to have a major influence on BMD, and inability to give informed consent. A total of 3,457 participants undergo a quantitative computed tomography (QCT) scan of the upper abdomen. The scanning parameters are as follows: 120 kVp at all centers, mAs between 75 and 200, FOV 40 cm×40 cm. The BMD values of L1 to L3 are measured, and the average BMD calculated. The American College of Radiology QCT criteria for the diagnosis of osteoporosis is applied to determine the presence of osteoporosis. The scout view images of T4-L4 vertebrae are reviewed by two experienced radiologists for semi-quantification of vertebral fractures according to Genant's method.

KEYWORDS:

Osteoporosis; bone mineral density; fracture

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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