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Onco Targets Ther. 2018 Aug 24;11:5143-5150. doi: 10.2147/OTT.S160178. eCollection 2018.

Peripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation.

Zhang J1,2, Chen X1,2, Rong G1,2, Xu T1,2, Zhao H1,2, Chen D1,2, Wu L1,2, Huang P1,2, Wang F1,2.

Author information

Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China,;
National Key Clinical Department of Laboratory Medicine, 210029, Nanjing, China,;



The main purpose of this study was to investigate the relationship among cytomegalovirus (CMV) viremia, peripheral immune cells alternations, and leukemia prognosis.

Patients and methods:

We studied 90 leukemia patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from 2008 to 2015. Their complete clinical laboratory data were collected until 1 year after transplantation.


All patients were serum CMV negative before allo-HSCT. After transplantation, the CMV reactivation group showed increased peripheral CD8+ T cells and decreased CD4+ T cells and B cells. However, CD8/CD4 ratio and B cells restored by control of CMV infection due to 2 months maximum course of ganciclovir treatment. CMV seropositivity was positively related to leukemia-free survival (LFS) of all recruited leukemia types.


In summary, CMV drives immune cell post-transplantation fluctuation, which also favors LFS of leukemia partly resulted from CD8+ T cells.


CD8+ T cells; allo-HSCT; cytomegalovirus; leukemia; leukemia-free survival

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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