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Onco Targets Ther. 2018 Aug 24;11:5143-5150. doi: 10.2147/OTT.S160178. eCollection 2018.

Peripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation.

Zhang J1,2, Chen X1,2, Rong G1,2, Xu T1,2, Zhao H1,2, Chen D1,2, Wu L1,2, Huang P1,2, Wang F1,2.

Author information

1
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China, hpj63@163.com; wangfang@njmu.edu.cn.
2
National Key Clinical Department of Laboratory Medicine, 210029, Nanjing, China, hpj63@163.com; wangfang@njmu.edu.cn.

Abstract

Background:

The main purpose of this study was to investigate the relationship among cytomegalovirus (CMV) viremia, peripheral immune cells alternations, and leukemia prognosis.

Patients and methods:

We studied 90 leukemia patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from 2008 to 2015. Their complete clinical laboratory data were collected until 1 year after transplantation.

Results:

All patients were serum CMV negative before allo-HSCT. After transplantation, the CMV reactivation group showed increased peripheral CD8+ T cells and decreased CD4+ T cells and B cells. However, CD8/CD4 ratio and B cells restored by control of CMV infection due to 2 months maximum course of ganciclovir treatment. CMV seropositivity was positively related to leukemia-free survival (LFS) of all recruited leukemia types.

Conclusion:

In summary, CMV drives immune cell post-transplantation fluctuation, which also favors LFS of leukemia partly resulted from CD8+ T cells.

KEYWORDS:

CD8+ T cells; allo-HSCT; cytomegalovirus; leukemia; leukemia-free survival

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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