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Leukemia. 2018 Sep 12. doi: 10.1038/s41375-018-0255-1. [Epub ahead of print]

CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase.

Author information

1
Hematology Department, Hospital Universitario Salamanca, Salamanca, Spain.
2
IBSAL, IBMCC-Cancer Research Center, University of Salamanca, Salamanca, Spain.
3
Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
4
Center of Molecular Biology and Gene Therapy, Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic.
5
Research Programon Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra, Barcelona, Spain.
6
Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
7
Hematology Department, Hospital Clínico Universitario of Valladolid, Valladolid, Spain.
8
Hematology Department, Hospital Universitario Salamanca, Salamanca, Spain. jmhr@usal.es.
9
IBSAL, IBMCC-Cancer Research Center, University of Salamanca, Salamanca, Spain. jmhr@usal.es.
10
Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic. pospisilova.sarka@fnbrno.cz.
11
Center of Molecular Biology and Gene Therapy, Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic. pospisilova.sarka@fnbrno.cz.
PMID:
30209402
DOI:
10.1038/s41375-018-0255-1

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