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Nature. 2018 Sep;561(7724):547-550. doi: 10.1038/s41586-018-0515-2. Epub 2018 Sep 12.

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections.

Author information

1
F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
2
Department of Neurology, Harvard Medical School, Boston, MA, USA.
3
Neurosurgery Department, Johns Hopkins School of Medicine, Baltimore, MD, USA.
4
Unit on Neural Circuits and Adaptive Behaviors, Clinical and Translational Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
5
Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
6
Department of Child Health Care, Children's Hospital of Nanjing Medical University, Nanjing, China.
7
Beth Israel Deaconess Medical Center, Boston, MA, USA.
8
Unit on Neural Circuits and Adaptive Behaviors, Clinical and Translational Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. wkuan@mail.nih.gov.
9
F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA. clifford.woolf@childrens.harvard.edu.
10
Department of Neurology, Harvard Medical School, Boston, MA, USA. clifford.woolf@childrens.harvard.edu.
11
Department of Neurobiology, Harvard Medical School, Boston, MA, USA. clifford.woolf@childrens.harvard.edu.
12
F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA. zhigang.he@childrens.harvard.edu.
13
Department of Neurology, Harvard Medical School, Boston, MA, USA. zhigang.he@childrens.harvard.edu.

Abstract

Current models of somatosensory perception emphasize transmission from primary sensory neurons to the spinal cord and on to the brain1-4. Mental influence on perception is largely assumed to occur locally within the brain. Here we investigate whether sensory inflow through the spinal cord undergoes direct top-down control by the cortex. Although the corticospinal tract (CST) is traditionally viewed as a primary motor pathway5, a subset of corticospinal neurons (CSNs) originating in the primary and secondary somatosensory cortex directly innervate the spinal dorsal horn via CST axons. Either reduction in somatosensory CSN activity or transection of the CST in mice selectively impairs behavioural responses to light touch without altering responses to noxious stimuli. Moreover, such CSN manipulation greatly attenuates tactile allodynia in a model of peripheral neuropathic pain. Tactile stimulation activates somatosensory CSNs, and their corticospinal projections facilitate light-touch-evoked activity of cholecystokinin interneurons in the deep dorsal horn. This touch-driven feed-forward spinal-cortical-spinal sensitization loop is important for the recruitment of spinal nociceptive neurons under tactile allodynia. These results reveal direct cortical modulation of normal and pathological tactile sensory processing in the spinal cord and open up opportunities for new treatments for neuropathic pain.

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PMID:
30209395
PMCID:
PMC6163083
DOI:
10.1038/s41586-018-0515-2
[Indexed for MEDLINE]
Free PMC Article

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