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J Diabetes Complications. 2018 Nov;32(11):995-999. doi: 10.1016/j.jdiacomp.2018.08.004. Epub 2018 Aug 9.

Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study.

Author information

1
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, USA. Electronic address: aalman@health.usf.edu.
2
Department of Biostatistical Sciences, Wake Forest School of Medicine, USA.
3
Barbara Davis Center, University of Colorado Denver, USA.
4
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, USA.
5
Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, USA.
6
Department of Metabolism, Endocrinology and Nutrition, University of Washington, USA.

Abstract

AIMS:

We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D).

METHODS:

A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later.

RESULTS:

PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants.

CONCLUSIONS:

Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.

KEYWORDS:

Arterial stiffness; Fibrinogen; Inflammation; Pulse wave analysis; Type 1 diabetes mellitus; Waist circumference

PMID:
30209019
PMCID:
PMC6174105
[Available on 2019-11-01]
DOI:
10.1016/j.jdiacomp.2018.08.004

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