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Curr Stem Cell Res Ther. 2019;14(2):93-116. doi: 10.2174/1574888X13666180912142028.

Chitosan in Biomedical Engineering: A Critical Review.

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Department of Chemical Engineering, Tabriz University, Tabriz, Iran.
Department of Chemical Engineering, Urmia University of Technology, Urmia, Iran.
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Department of Microbiology, College of Basic Science, Islamic Azad University, Shiraz Branch, Shiraz, Iran.
Departments of Resin and Additives, Institute for Color Science and Technology, P.O. Box 16765-654, Tehran, Iran.
Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran.
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.


Biomedical engineering seeks to enhance the quality of life by developing advanced materials and technologies. Chitosan-based biomaterials have attracted significant attention because of having unique chemical structures with desired biocompatibility and biodegradability, which play different roles in membranes, sponges and scaffolds, along with promising biological properties such as biocompatibility, biodegradability and non-toxicity. Therefore, chitosan derivatives have been widely used in a vast variety of uses, chiefly pharmaceuticals and biomedical engineering. It is attempted here to draw a comprehensive overview of chitosan emerging applications in medicine, tissue engineering, drug delivery, gene therapy, cancer therapy, ophthalmology, dentistry, bio-imaging, bio-sensing and diagnosis. The use of Stem Cells (SCs) has given an interesting feature to the use of chitosan so that regenerative medicine and therapeutic methods have benefited from chitosan-based platforms. Plenty of the most recent discussions with stimulating ideas in this field are covered that could hopefully serve as hints for more developed works in biomedical engineering.


Chitosan; biomaterial; biomedical engineering; gene therapy; stem cell; tissue engineering.

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