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Amino Acids. 2018 Nov;50(11):1511-1524. doi: 10.1007/s00726-018-2650-3. Epub 2018 Sep 11.

Regulation of glucose and lipid metabolism by the pancreatic and extra-pancreatic actions of taurine.

Author information

1
NUPEM, Universidade Federal do Rio de Janeiro, Campus UFRJ-Macaé, Avenida São José do Barreto, 764, Macaé, RJ, CEP: 27965-045, Brazil. rosaneribeirobio@gmail.com.
2
Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, Brazil.
3
Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Abstract

The beneficial actions of L-taurine (Tau) against glucose intolerance, obesity, type 2 diabetes (T2D), and non-alcoholic fat liver disease (NAFLD) have been linked to its antioxidant and anti-inflammatory effects, which ameliorate tissue insulin sensitivity. Importantly, there are several lines of evidence that indicate a direct action of Tau on the endocrine pancreas to regulate the secretion and paracrine actions of insulin, glucagon, and somatostatin. Furthermore, Tau can also ameliorate glucose metabolism through the enhancement of insulin signaling. However, some of the benefits of Tau upon intermediary metabolism may manifest via considerable antagonism of the action of insulin. Therefore, this review discusses the mechanisms of action by which Tau may regulate endocrine pancreatic morphofunction, and glucose and lipid homeostasis.

KEYWORDS:

Glucagon; Glucose intolerance; Insulin; Non-alcoholic fat liver disease; Somatostatin; Supplementation

PMID:
30206707
DOI:
10.1007/s00726-018-2650-3
[Indexed for MEDLINE]

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