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Int J Mol Sci. 2018 Sep 8;19(9). pii: E2665. doi: 10.3390/ijms19092665.

Selenium-Related Transcriptional Regulation of Gene Expression.

Author information

1
Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning, Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. mikko.lammi@umu.se.
2
Department of Integrative Medical Biology, University of Umeå, 901 87 Umeå, Sweden. mikko.lammi@umu.se.
3
Department of Integrative Medical Biology, University of Umeå, 901 87 Umeå, Sweden. chengjuan.qu@umu.se.

Abstract

The selenium content of the body is known to control the expression levels of numerous genes, both so-called selenoproteins and non-selenoproteins. Selenium is a trace element essential to human health, and its deficiency is related to, for instance, cardiovascular and myodegenerative diseases, infertility and osteochondropathy called Kashin⁻Beck disease. It is incorporated as selenocysteine to the selenoproteins, which protect against reactive oxygen and nitrogen species. They also participate in the activation of the thyroid hormone, and play a role in immune system functioning. The synthesis and incorporation of selenocysteine occurs via a special mechanism, which differs from the one used for standard amino acids. The codon for selenocysteine is a regular in-frame stop codon, which can be passed by a specific complex machinery participating in translation elongation and termination. This includes a presence of selenocysteine insertion sequence (SECIS) in the 3'-untranslated part of the selenoprotein mRNAs. Nonsense-mediated decay is involved in the regulation of the selenoprotein mRNA levels, but other mechanisms are also possible. Recent transcriptional analyses of messenger RNAs, microRNAs and long non-coding RNAs combined with proteomic data of samples from Keshan and Kashin⁻Beck disease patients have identified new possible cellular pathways related to transcriptional regulation by selenium.

KEYWORDS:

nonsense-mediated decay; selenium; selenocysteine; selenocysteine insertion sequence; selenoproteins

PMID:
30205557
PMCID:
PMC6163693
DOI:
10.3390/ijms19092665
[Indexed for MEDLINE]
Free PMC Article

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