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Genes (Basel). 2018 Sep 7;9(9). pii: E448. doi: 10.3390/genes9090448.

Epigenetic Control of Pancreatic Regeneration in Diabetes.

Author information

1
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France. sbalaji@unice.fr.
2
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France. tiziana.napolitano@unice.fr.
3
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France. serena.silvano@unice.fr.
4
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France. marika-elsa.friano@unice.fr.
5
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France. anna.garrido-utrilla@unice.fr.
6
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France. josipa.atlija@unice.fr.
7
Université Nice Sophia Antipolis, Inserm, CNRS, iBV, FR-06100 Nice, France. collombat@unice.fr.

Abstract

Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development, making use of diverse cell sources or converting pre-existing pancreatic cells. Despite impressive progresses and promising successes, it appears that we still need to gain further insight into the molecular mechanisms underlying β-cell development. This becomes even more obvious with the emergence of a relatively new field of research, epigenetics. The current review therefore focuses on the latest advances in this field in the context of β-cell (neo-)genesis research.

KEYWORDS:

diabetes; epigenetics; pancreas; regeneration

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