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Neurobiol Aging. 2018 Dec;72:32-39. doi: 10.1016/j.neurobiolaging.2018.08.007. Epub 2018 Aug 11.

Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies.

Author information

1
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
2
McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Canada.
3
Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
4
Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea.
5
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. Electronic address: romel79@yuhs.ac.

Abstract

Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.

KEYWORDS:

Amyloid imaging; Amyloid-beta; Brain atrophy; Dementia with Lewy bodies

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