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Dev Cell. 2018 Sep 10;46(5):529-530. doi: 10.1016/j.devcel.2018.08.020.

A Dilution Model for Embryonic Scaling.

Author information

1
Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: wallace.marshall@ucsf.edu.

Abstract

A recent study in Nature Cell Biology (Almuedo-Castillo et al., 2018) describes a mechanism for tissue scaling in zebrafish embryos. The authors show that a fixed relative amount of the diffusible Nodal inhibitor Lefty produces an extended gradient in larger embryos, ensuring proportionally scaled germ layers, irrespective of embryo size.

PMID:
30205035
DOI:
10.1016/j.devcel.2018.08.020
[Indexed for MEDLINE]
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