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Sci Data. 2018 Sep 11;5:180185. doi: 10.1038/sdata.2018.185.

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease.

Wang M1,2, Beckmann ND1,2, Roussos P1,2,3,4,5, Wang E1,2, Zhou X1,2, Wang Q1,2, Ming C1,2, Neff R1,2, Ma W1,2, Fullard JF1,3,4, Hauberg ME3,4,6,7,8, Bendl J1,3,4, Peters MA9, Logsdon B9, Wang P1,2, Mahajan M1,2, Mangravite LM9, Dammer EB10,11, Duong DM10,11, Lah JJ12,13, Seyfried NT10,11,12, Levey AI12,13, Buxbaum JD1,3,4,14,15, Ehrlich M16,17, Gandy S5,16,18, Katsel P3,5, Haroutunian V3,5,18,15, Schadt E1,2, Zhang B1,2.

Author information

1
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
2
Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
3
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
4
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
5
Psychiatry, JJ Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.
6
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus 8000, Denmark.
7
Department of Biomedicine, Aarhus University, Aarhus, Aarhus, 8000, Denmark.
8
Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, 8000, Denmark.
9
Sage Bionetworks, 1100 Fairview Ave N, Seattle, WA 98109, USA.
10
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
11
Integrated Proteomics Core Facility, Emory University School of Medicine, Atlanta, GA 30322, USA.
12
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
13
Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.
14
Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
15
Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
16
Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York NY 10029, USA.
17
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA.
18
The Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA.

Abstract

Alzheimer's disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive cognitive disability. Genetic and genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these risk loci fail to account for the majority of affected cases and can neither provide clinically meaningful prediction of development of AD nor offer actionable mechanisms. This cohort study generated large-scale matched multi-Omics data in AD and control brains for exploring novel molecular underpinnings of AD. Specifically, we generated whole genome sequencing, whole exome sequencing, transcriptome sequencing and proteome profiling data from multiple regions of 364 postmortem control, mild cognitive impaired (MCI) and AD brains with rich clinical and pathophysiological data. All the data went through rigorous quality control. Both the raw and processed data are publicly available through the Synapse software platform.

PMID:
30204156
PMCID:
PMC6132187
DOI:
10.1038/sdata.2018.185
[Indexed for MEDLINE]
Free PMC Article

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