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Psychooncology. 2018 Dec;27(12):2770-2777. doi: 10.1002/pon.4886. Epub 2018 Sep 27.

Sexual dysfunction and reproductive concerns in young women with breast cancer: Type, prevalence, and predictors of problems.

Author information

1
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
2
Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
3
Regional Cancer Centre, Uppsala-Örebro, Uppsala, Sweden.
4
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
5
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
6
Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
7
College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.

Abstract

OBJECTIVE:

A dearth of studies focusing on young women (<40 years) with breast cancer have hampered the understanding of the type, prevalence, and predictors of sexual dysfunction and reproductive concerns in this population.

METHODS:

Data were collected from 181 women (response rate = 60%) diagnosed with breast cancer approximately 2 years previously (age 21-39) using the Swedish National Quality Registry for Breast Cancer and a survey including standardized measures of sexual dysfunction, reproductive concerns, body image, and health-related quality of life. Multivariable logistic binary regression analyses were used to identify predictors of sexual dysfunction and reproductive concerns.

RESULTS:

Sexual dysfunction in at least one domain was reported by 68% of the women, and a high level of reproductive concerns in at least one dimension was reported by 58%. Model results showed that current endocrine treatment was a significant predictor of dysfunction related to lubrication (OR 3.8, 95% CI 1.2-12.1) and vaginal discomfort (OR 8.7, 95% CI 1.5-51.5). Negative body image was related to satisfaction with sex life (OR 1.1, 95% CI 1.0-1.2). A high level of reproductive concerns was predicted by a wish for (additional) children in the future (OR 3.4, 95% CI 1.1-10.2) and by previous chemotherapy (OR 2.5, 95% CI 1.1-5.9).

CONCLUSIONS:

Sexual dysfunction and reproductive concerns are common in young women with breast cancer. Current endocrine treatment, previous chemotherapy, a negative body image, and a wish for children in the future predict higher level of problems.

KEYWORDS:

body image; breast cancer; cancer; oncology; quality of life; reproductive concerns; sexual function; young

PMID:
30203884
DOI:
10.1002/pon.4886

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