Analysis of the drug therapy of gatifloxacin and levofloxacin in the treatment of acute bacterial conjunctivitis

Pak J Pharm Sci. 2018 Jul;31(4(Special)):1757-1760.

Abstract

Acute bacterial conjunctivitis is an acute conjunctivitis that is frequently transmitted in summer and autumn. It is a common and frequently occurring disease in ophthalmology clinic. Gatifloxacin is an effective antibacterial drug. It not only maintains the antibacterial effect of the three generation of fluoroquinolones on Gram-negative bacteria, but also enhances the effectiveness of gatifloxacin, including other Gram-positive bacteria and anaerobes. In this paper, by taking gatifloxacin eye drops as the experimental drug and levofloxacin as the control drug, we conducted a double-blind randomized controlled clinical trial to evaluate the efficacy and safety of gatifloxacin eye drops in the treatment of acute bacterial conjunctivitis. The clinical results showed that the total effective rate of the Gatifloxacin treatment group was 95%. Conclusion shows that gatifloxacin is a safe and effective antibiotic eye drops. It has broad antibacterial spectrum, strong antibacterial activity and effective clinical treatment, and it can effectively treat acute bacterial conjunctivitis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Conjunctivitis, Bacterial / drug therapy*
  • Double-Blind Method
  • Female
  • Gatifloxacin / administration & dosage
  • Gatifloxacin / adverse effects
  • Gatifloxacin / therapeutic use*
  • Humans
  • Levofloxacin / administration & dosage
  • Levofloxacin / adverse effects
  • Levofloxacin / therapeutic use*
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Ophthalmic Solutions / therapeutic use
  • Young Adult

Substances

  • Ophthalmic Solutions
  • Levofloxacin
  • Gatifloxacin