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Tissue Eng Part A. 2019 Apr;25(7-8):538-553. doi: 10.1089/ten.TEA.2018.0142. Epub 2018 Oct 31.

A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment.

Author information

1
1 Department of Biomedical Engineering, Columbia University , New York, New York.
2
2 Department of Orthopedic Surgery, Columbia University , New York, New York.
3
3 Department of Mechanical Engineering, Columbia University , New York, New York.

Abstract

The synovium envelops the diarthrodial joint and plays a key regulatory role in defining the composition of the synovial fluid through filtration and biosynthesis of critical boundary lubricants. Synovium changes often precede cartilage damage in osteoarthritis. We describe a novel in vitro tissue engineered model, validated against native synovium explants, to investigate the structure-function of synovium through quantitative solute transport measures. Synovium was evaluated in the presence of a proinflammatory cytokine, interleukin-1, or the clinically relevant corticosteroid, dexamethasone. We anticipate that a better understanding of synovium transport would support efforts to develop more effective strategies aimed at restoring joint health.

KEYWORDS:

models; osteoarthritis; solute transport; synovium

PMID:
30203722
PMCID:
PMC6482911
[Available on 2020-04-01]
DOI:
10.1089/ten.TEA.2018.0142

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