Format

Send to

Choose Destination
J Infect Dis. 2018 Sep 7. doi: 10.1093/infdis/jiy523. [Epub ahead of print]

Seropositivity to multiple anogenital HPV types is associated with current anogenital HPV infection, abnormal cytology and seropositivity for non-genital HPVs.

Author information

1
Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
2
Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška, Ljubljana, Slovenia.
3
Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Background:

Antibodies against human papillomaviruses (HPV) are biomarkers for current or past infections. We assessed whether antibodies against multiple HPV types were determinants of current multiple anogenital HPV infections, abnormal cytology and seropositivity for cutaneous HPVs.

Methods:

1,848 Slovenian women attended two rounds of cervical cancer screening three years apart and provided data on HPV antibodies and HPV DNA at both visits. Antibodies against 15 anogenital HPV types and 6 cutaneous HPVs were determined using pseudovirion-luminex serology and anogenital HPV DNA using Linear Array. Antibodies to polyomaviruses were evaluated as a control. Women were grouped as either HPV seronegative, having antibodies to 1-2 HPV types or to ≥ 3 HPV types.

Results:

Presence of antibodies to multiple anogenital HPV types at baseline was associated strongly with (i) presence of HPV DNA at the cervix (χ2=68.8;p<0.0001), (ii) multiple types of HPV DNA at baseline (χ2=58.6; p<0.0001), (iii) HPV DNA at follow-up (χ2= 22.9; p<0.0001) (iv) abnormal cytology (χ2=9.8; p=0.0017), (v) concomitant presence of antibodies to any of six non-genital HPV types (χ2=40.1;p<0.0001). Presence of antibodies to ≥3 anogenital HPV types tended to persist over time.

Conclusions:

Seropositivity against at least 3 anogenital HPV types is associated with current multiple anogenital HPV infections, abnormal cytology and seropositivity to non-genital HPVs.

PMID:
30202984
DOI:
10.1093/infdis/jiy523

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center