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Philos Trans R Soc Lond B Biol Sci. 2018 Sep 10;373(1758). pii: 20170366. doi: 10.1098/rstb.2017.0366.

Connectome to behaviour: modelling Caenorhabditis elegans at cellular resolution.

Author information

1
OpenWorm Foundation, Boston, MA, USA stephen@openworm.org.
2
OpenWorm Foundation, Boston, MA, USA.
3
Department of Neuroscience, Physiology and Pharmacology, University College London WC1E 6BT, UK.
4
MRC London Institute of Medical Sciences, London W12 0N, UK.
5
Institute of Clinical Sciences, Imperial College London, London SW7 2AZ, UK.

Abstract

It has been 30 years since the 'mind of the worm' was published in Philosophical Transactions B (White et al 1986 Phil. Trans. R. Soc. Lond. B314, 1-340). Predicting Caenorhabditis elegans' behaviour from its wiring diagram has been an enduring challenge since then. This special theme issue of Philosophical Transactions B combines research from neuroscientists, physicists, mathematicians and engineers to discuss advances in neural activity imaging, behaviour quantification and multiscale simulations, and how they are bringing the goal of whole-animal modelling at cellular resolution within reach.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.

KEYWORDS:

Caenorhabditis elegans; behaviour; connectome; nervous system; open data; simulation

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