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Philos Trans R Soc Lond B Biol Sci. 2018 Sep 10;373(1758). pii: 20170366. doi: 10.1098/rstb.2017.0366.

Connectome to behaviour: modelling Caenorhabditis elegans at cellular resolution.

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OpenWorm Foundation, Boston, MA, USA
OpenWorm Foundation, Boston, MA, USA.
Department of Neuroscience, Physiology and Pharmacology, University College London WC1E 6BT, UK.
MRC London Institute of Medical Sciences, London W12 0N, UK.
Institute of Clinical Sciences, Imperial College London, London SW7 2AZ, UK.


It has been 30 years since the 'mind of the worm' was published in Philosophical Transactions B (White et al 1986 Phil. Trans. R. Soc. Lond. B314, 1-340). Predicting Caenorhabditis elegans' behaviour from its wiring diagram has been an enduring challenge since then. This special theme issue of Philosophical Transactions B combines research from neuroscientists, physicists, mathematicians and engineers to discuss advances in neural activity imaging, behaviour quantification and multiscale simulations, and how they are bringing the goal of whole-animal modelling at cellular resolution within reach.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.


Caenorhabditis elegans; behaviour; connectome; nervous system; open data; simulation

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