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Cells. 2018 Sep 1;7(9). pii: E130. doi: 10.3390/cells7090130.

Genetic Renal Diseases: The Emerging Role of Zebrafish Models.

Author information

1
Department of Pediatric Nephrology & Development and Regeneration, University Hospitals Leuven, KU Leuven-University of Leuven, Herestraat 49, Box 817, 3000 Leuven, Belgium. mohamed.abdelmonem@kasralainy.edu.eg.
2
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, 11628 Cairo, Egypt. mohamed.abdelmonem@kasralainy.edu.eg.
3
Department of Pediatric Nephrology & Development and Regeneration, University Hospitals Leuven, KU Leuven-University of Leuven, Herestraat 49, Box 817, 3000 Leuven, Belgium. santeprinciero.berlingerio@kuleuven.be.
4
Department of Pediatric Nephrology & Development and Regeneration, University Hospitals Leuven, KU Leuven-University of Leuven, Herestraat 49, Box 817, 3000 Leuven, Belgium. bert.vandenheuvel@med.kuleuven.be.
5
Department of Pediatric Nephrology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands. bert.vandenheuvel@med.kuleuven.be.
6
Laboratory for Molecular Bio-Discovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven-University of Leuven, 3000 Leuven, Belgium. peter.dewitte@kuleuven.be.
7
Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK. martin.p.lowe@manchester.ac.uk.
8
Department of Pediatric Nephrology & Development and Regeneration, University Hospitals Leuven, KU Leuven-University of Leuven, Herestraat 49, Box 817, 3000 Leuven, Belgium. elena.levtchenko@uzleuven.be.

Abstract

The structural and functional similarity of the larval zebrafish pronephros to the human nephron, together with the recent development of easier and more precise techniques to manipulate the zebrafish genome have motivated many researchers to model human renal diseases in the zebrafish. Over the last few years, great advances have been made, not only in the modeling techniques of genetic diseases in the zebrafish, but also in how to validate and exploit these models, crossing the bridge towards more informative explanations of disease pathophysiology and better designed therapeutic interventions in a cost-effective in vivo system. Here, we review the significant progress in these areas giving special attention to the renal phenotype evaluation techniques. We further discuss the future applications of such models, particularly their role in revealing new genetic diseases of the kidney and their potential use in personalized medicine.

KEYWORDS:

CRISPR; genetic renal diseases; morpholino; new therapies; pathophysiology; pronephros; zebrafish

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