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Medicine (Baltimore). 2018 Sep;97(36):e11832. doi: 10.1097/MD.0000000000011832.

Effect of single-dose intravenous dexamethasone on subjective voice quality after thyroidectomy: A meta-analysis.

Author information

1
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University.
2
Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju.
3
Department of Practical Music, SoHae University, Gunsan.
4
Presbyterian Medical Center, Department of Internal Medicine, Division of Allergy and Pulmonology, Jeonju, Republic of Korea.

Abstract

BACKGROUND:

Corticosteroids are widely used to treat voice change after thyroidectomy. In this study, we evaluated the effect of a single dose of intravenous dexamethasone after thyroidectomy using a metaanalysis.

METHODS:

Relevant studies were identified by searching the following databases: Medline, Embase, and Cochrane through February 2017. We followed PRISMA guidelines. The following search terms were used: "thyroidectomy," "voice," "steroid." Random-effects models were used to estimate standardized mean differences (SMDs) and 95% confidence intervals.

RESULTS:

Our search yielded one retrospective cohort study involving 122 thyroidectomy patients and 3 randomized controlled studies involving 242 thyroidectomy patients. The pooled SMD for voice quality after thyroidectomy was -0.80 (P < .05). Subgroup analysis showed significant voice quality change 1 day after administration of dexamethasone.

CONCLUSIONS:

Single-dose intravenous dexamethasone after thyroidectomy significantly improves subjective voice quality on day 1. The effect was not different significantly after day 1.

LEVEL OF EVIDENCE:

Level 2a.

PMID:
30200067
PMCID:
PMC6133636
DOI:
10.1097/MD.0000000000011832
[Indexed for MEDLINE]
Free PMC Article

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