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Hum Fertil (Camb). 2018 Sep 9:1-10. doi: 10.1080/14647273.2018.1504325. [Epub ahead of print]

Genetic aspects of idiopathic asthenozoospermia as a cause of male infertility.

Author information

1
a Reproductive Biotechnology Research Centre, Avicenna Research Institute, ACECR , Tehran , Iran.
2
b Department of Medical Genetics School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
3
c Genetics Research Centre University of Social Welfare and Rehabilitation Sciences , Tehran , Iran.

Abstract

Infertility is a worldwide problem affecting about 15% of couples trying to conceive. Asthenozoospermia (AZS) is one of the major causes of male infertility, diagnosed by reduced sperm motility, and has no effective therapeutic treatment. To date, a few genes have been found to be associated with AZS in humans and mice, but in most of cases its molecular aetiology remains unknown. Genetic causes of AZS may include chromosomal abnormalities, specific mutations of nuclear and mitochondrial genes. However recently, epigenetic factors, altered microRNAs expression signature, and proteomics have shed light on the pathophysiological basis of AZS. This review article summarises the reported genetic causes of AZS.

KEYWORDS:

Male infertility; asthenozoospermia; epigenetic; genetics

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