Send to

Choose Destination
Trends Endocrinol Metab. 2018 Oct;29(10):686-698. doi: 10.1016/j.tem.2018.08.002. Epub 2018 Sep 6.

Nutritional Modulation of Innate Immunity: The Fat-Bile-Gut Connection.

Author information

Institute for Cardiovascular Prevention, LMU Munich, Munich, Germany. Electronic address:
Institute for Cardiovascular Prevention, LMU Munich, Munich, Germany.
Institute for Cardiovascular Prevention, LMU Munich, Munich, Germany; Department of Physiology and Pharmacology (FyFa) and Department of Medicine, Karolinska Institutet, Stockholm, Sweden; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address:


Altered nutritional behavior in Western societies has unleashed numerous metabolic disorders, intimately linked to profound disruptions of the immune system. Here we summarize how nutrition modulates innate immunity. We outline recent findings regarding nutrient signaling and we particularly focus on the collateral impact of nutrition on the microbiome and on the bile acid (BA) pool. We discuss how the integration of postprandial signals by the gut microbiota, along with the absorption routes of metabolites, differentially affects immune niches to orchestrate immune responses. Finally, we discuss the potential consequences of these signals in the light of trained immunity. A better understanding of nutrition signaling will permit the optimization of therapeutic and dietary strategies against the arising immune disorders.


bile acids; gut microbiome; innate immunity; nutrition; trained immunity

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center