Format

Send to

Choose Destination
J Neuroimmunol. 2018 Oct 15;323:105-108. doi: 10.1016/j.jneuroim.2018.08.004. Epub 2018 Aug 8.

CTLA-4, PD-1 and TIM-3 expression predominantly downregulated in MS patients.

Author information

1
Department of Immunology and genetic, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: A.mohimm@gmail.com.
2
Department of Genetics, Urmia University of Medical Sciences, Urmia, Iran.
3
Department of Neurology, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.

Abstract

Multiple sclerosis (MS), is an autoimmune disorder of central nervous system (CNS) characterized by inflammation and demyelination. Self-tolerance impairment is considered to be induced by a combination of inherited susceptibility and environmental agents. In this work, we demonstrate that a reduction in the comparative expression of well-known inhibitory receptors (i.e., CTLA-4, PD-1, and TIM-3) is importantly linked with MS patients compared to healthy controls. The relative expression of interested genes was performed on peripheral blood mononuclear cells (PBMCs), by using quantitative real time-PCR (qRT-PCR). Our data highlighted the role of inhibitory receptors in the maintenance of immune homeostasis in autoimmune disease.

KEYWORDS:

CTLA-4; Multiple sclerosis; PD-1; TIM-3

PMID:
30196822
DOI:
10.1016/j.jneuroim.2018.08.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center