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Korean J Parasitol. 2018 Aug;56(4):391-396. doi: 10.3347/kjp.2018.56.4.391. Epub 2018 Aug 31.

Genetic Diversity of Echinococcus granulosus Genotype G1 in Xinjiang, Northwest of China.

Author information

1
School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region 832002, People's Republic of China.
2
College of Animal Science, Tarim University, Alar City, Xinjiang 843300, PR China.
3
Department of Infectious Diseases, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
4
School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region 832002, People's Republic of China.
5
Institue of Veterinary Sciences, Academy of Military Medical Sciences, Jilin, Changchun, 1300062, People's Republic of China.

Abstract

Cystic echinococcosis (CE) caused by E. granulosus is a serious helminthic zoonosis in humans, livestock and wildlife. Xinjiang is one of high endemic province for CE in China. A total of 55 sheep and cattle livers containing echinococcal cysts were collected from slaughterhouses in Changji and Yining City, northern region of Xinjiang. PCR was employed for cloning 2 gene fragments, 12S rRNA and CO1 for analysis of phylogenetic diversity of E. granulosus. The results showed that all the samples collected were identified as G1 genotype of E. granulosus. Interestingly, YL5 and CJ75 strains were the older branches compared to those strains from France, Argentina, Australia. CO1 gene fragment showed 20 new genotype haploids and 5 new genotype haplogroups (H1-H5) by the analysis of Network 5.0 software, and the YLY17 strain was identified as the most ancestral haplotype. The major haplotypes, such as CJ75 and YL5 strains, showed identical to the isolates from Middle East. The international and domestic trade of livestock might contribute to the dispersal of different haplotypes for E. granulosus evolution.

KEYWORDS:

CO1 gene; Echinococcus granulosus; cystic echinococcosis; northwest China

PMID:
30196674
PMCID:
PMC6137305
DOI:
10.3347/kjp.2018.56.4.391
[Indexed for MEDLINE]
Free PMC Article

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