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Trends Immunol. 2018 Oct;39(10):771-774. doi: 10.1016/j.it.2018.08.004. Epub 2018 Sep 5.

Hiding in Plain Sight: Soluble Immunomodulatory Receptors.

Author information

1
Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address: L.N.Dahal@soton.ac.uk.
2
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
3
Immunity, Infection and Inflammation Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

Abstract

Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.

PMID:
30195467
DOI:
10.1016/j.it.2018.08.004
[Indexed for MEDLINE]

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