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Food Chem Toxicol. 2018 Nov;121:237-245. doi: 10.1016/j.fct.2018.08.078. Epub 2018 Sep 6.

Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells.

Author information

1
Department of Pathology, Botucatu Medical School, UNESP, Botucatu, SP, Brazil. Electronic address: mariana.fragoso@fccc.edu.
2
Department of Pathology, Botucatu Medical School, UNESP, Botucatu, SP, Brazil. Electronic address: romualdo.gr15@gmail.com.
3
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address: Lisa.Vanderveer@fccc.edu.
4
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address: Janusz.FrancoBarraza@fccc.edu.
5
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address: Edna.Cukierman@fccc.edu.
6
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address: Margie.Clapper@fccc.edu.
7
Department of Morphology, Institute of Biosciences of Botucatu, UNESP, Botucatu, SP, Brazil. Electronic address: rcarvalho@ibb.unesp.br.
8
Department of Morphology, Institute of Biosciences of Botucatu, UNESP, Botucatu, SP, Brazil. Electronic address: barbisan@ibb.unesp.br.

Abstract

This study evaluated the possible protective effects of lyophilized açaí pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7.5% lyophilized AP. The findings indicate: 1) C3R (25 μM) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). Thus, lyophilized AP could exert a potential antitumor activity.

KEYWORDS:

Colitis; Colon carcinogenesis; Cyanidin 3-rutinoside; Lyophilized açaí pulp; Prevention

PMID:
30194994
DOI:
10.1016/j.fct.2018.08.078
[Indexed for MEDLINE]

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