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Sci China Life Sci. 2018 Oct;61(10):1205-1211. doi: 10.1007/s11427-018-9331-y. Epub 2018 Sep 4.

The intestinal epithelial response to damage.

Author information

1
Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, 94143, USA.
2
Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, 6041, Belgium.
3
Laboratory of Experimental Gastroenterology, Université libre de Bruxelles, Brussels, 1070, Belgium.
4
Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, 94143, USA. ophir.klein@ucsf.edu.
5
Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, CA, 94143, USA. ophir.klein@ucsf.edu.

Abstract

The constant renewal of the intestinal epithelium is fueled by intestinal stem cells (ISCs) lying at the base of crypts, and these ISCs continuously give rise to transit-amplifying progenitor cells during homeostasis. Upon injury and loss of ISCs, the epithelium has the ability to regenerate by the dedifferentiation of progenitor cells that then regain stemness and repopulate the pool of ISCs. Epithelial cells receive cues from immune cells, mesenchymal cells and the microbiome to maintain homeostasis. This review focuses on the response of the epithelium to damage and the interplay between the different intestinal compartments.

KEYWORDS:

intestine; microenvironment; regeneration

PMID:
30194677
DOI:
10.1007/s11427-018-9331-y
[Indexed for MEDLINE]

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