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Nat Commun. 2018 Sep 7;9(1):3653. doi: 10.1038/s41467-018-06093-5.

Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment.

Xue X1, Huang Y1,2, Bo R1, Jia B1, Wu H1, Yuan Y1, Wang Z1,3, Ma Z1, Jing D1,4, Xu X1, Yu W1,5, Lin TY6, Li Y7.

Author information

1
Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA.
2
Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, 310021, China.
3
Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
4
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
5
Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
6
Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, 95817, USA.
7
Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA. lypli@ucdavis.edu.

Abstract

Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment.

PMID:
30194413
PMCID:
PMC6128896
DOI:
10.1038/s41467-018-06093-5
[Indexed for MEDLINE]
Free PMC Article

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