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Drug Metab Pharmacokinet. 2018 Oct;33(5):228-231. doi: 10.1016/j.dmpk.2018.08.001. Epub 2018 Aug 14.

HLA-B*58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population.

Author information

1
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address: pumchdyl36@163.com.
2
Wuhan YZY Medical Science and Technology Co Ltd., Wuhan, China.
3
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Abstract

HLA-B*58:01 has been demonstrated to be associated with allopurinol-induced severe cutaneous adverse reactions. Since HLA-B*58:01 is too complicated to be identified, it is necessary to select an appropriate surrogate biomarker. In Japan, the rs9263726 allele was considered as a surrogate biomarker for HLA-B*58:01, but this was not the case with the Australian cohort. Due to the conflict results, in this study, we aim to demonstrate whether the rs9263726 allele is a surrogate biomarker for HLA-B*58:01 in Han Chinese population. A total of 353 samples (200 cases from the south and 153 cases from the north) were selected to detect HLA-B*58:01 and rs9263726 allele. The HLA-B*58:01 was identified by sequencing-based method, and the rs9263726 allele was identified by Taqman SNP Genotyping Assays. The results showed that the two alleles had a linkage, but not absolute linkage disequilibrium in Han Chinese population.

KEYWORDS:

Allopurinol-induced SCARs; HLA-B*58:01; Han Chinese; Linkage disequilibrium; rs9263726

PMID:
30193812
DOI:
10.1016/j.dmpk.2018.08.001
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