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Cell. 2018 Sep 6;174(6):1571-1585.e11. doi: 10.1016/j.cell.2018.08.042.

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks.

Author information

1
Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
2
Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764 Neuherberg Germany.
3
Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, Irvine, CA 92697, USA.
4
Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK.
5
Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
6
Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA.
7
BESE Division, KAUST Environmental Epigenetics Program, King Abdullah University Science and Technology, Thuwal, Saudi Arabia.
8
German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764 Neuherberg Germany; Chair of Experimental Genetics, Technical University of Munich, 85350 Freising-Weihenstephan, Germany. Electronic address: adamski@helmholtz-muenchen.de.
9
Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technical University of Munich, 80333 Munich, Germany. Electronic address: matthias.tschoep@helmholtz-muenchen.de.
10
Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: kristin.l.mahan@uth.tmc.edu.
11
Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: psc@uci.edu.

Abstract

Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously. We present a temporal and spatial atlas of circadian metabolism in the context of systemic energy balance and under chronic nutrient stress (high-fat diet [HFD]). Comparative analysis reveals how the repertoires of tissue metabolism are linked and gated to specific temporal windows and how this highly specialized communication and coherence among tissue clocks is rewired by nutrient challenge. Overall, we illustrate how dynamic metabolic relationships can be reconstructed across time and space and how integration of circadian metabolomics data from multiple tissues can improve our understanding of health and disease.

KEYWORDS:

CircadiOmics; circadian rhythms; clock; high-fat diet; metabolism; metabolomics

PMID:
30193114
PMCID:
PMC6501776
[Available on 2019-09-06]
DOI:
10.1016/j.cell.2018.08.042
[Indexed for MEDLINE]

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