Format

Send to

Choose Destination
Cell. 2018 Sep 6;174(6):1347-1360. doi: 10.1016/j.cell.2018.08.027.

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment.

Author information

1
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: samuel.bakhoum@gmail.com.
2
Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.

Abstract

Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing double-stranded DNA into the cytosol, engaging the cGAS-STING anti-viral pathway. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.

PMID:
30193109
PMCID:
PMC6136429
[Available on 2019-09-06]
DOI:
10.1016/j.cell.2018.08.027
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center