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Mol Cell. 2018 Sep 6;71(5):649-651. doi: 10.1016/j.molcel.2018.08.032.

Pour Some Sugar on TDP(-43).

Author information

1
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
2
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.

Abstract

In this issue of Molecular Cell, McGurk et al. (2018) identify how poly(ADP-ribose) binding tunes the phase behavior of the ALS disease protein TDP-43, uncovering the molecular events underlying its aggregation in disease and illuminating a novel therapeutic target.

PMID:
30193092
DOI:
10.1016/j.molcel.2018.08.032
[Indexed for MEDLINE]

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