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J Agric Food Chem. 2018 Oct 3;66(39):10132-10138. doi: 10.1021/acs.jafc.8b03177. Epub 2018 Sep 20.

Insecticide Exposure and Development of Nonalcoholic Fatty Liver Disease.

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Department of Food Science , University of Massachusetts Amherst , 102 Holdsworth Way , Amherst , Massachusetts 01003 , United States.


Nonalcoholic fatty liver disease (NAFLD) is the prevalent liver disease resulting from metabolic disorder, which is highly associated with obesity and type 2 diabetes. Emerging evidence has shown that insecticide exposure disrupts lipid and glucose metabolism and results in obesity and type 2 diabetes. However, the potential impact of insecticide exposure on the liver functions related to NAFLD development is largely unknown. Thus, this perspective focused on the current knowledge of the effect of insecticides on the liver functions, particularly lipid and glucose metabolism, as well as other liver functions to correlate insecticide exposure and the development of NAFLD.


NAFLD; glucose metabolism; insecticides; lipid metabolism; oxidative stress

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