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Clin Infect Dis. 2019 Feb 15;68(5):854-856. doi: 10.1093/cid/ciy666.

Complement 5a Receptor Polymorphisms Are Associated With Panton-Valentine Leukocidin-positive Staphylococcus aureus Colonization in African Pygmies.

Author information

1
Institute of Medical Microbiology, University Hospital Münster.
2
Core Facility Genomics, University of Münster, Germany.
3
Hôpital Albert Schweitzer.
4
Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon.
5
Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Deutsches Zentrum für Infektionsforschung.
6
Institute of Medical Microbiology, University Hospital Jena.
7
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
8
Vietnamese-German Center for Medical Research, Hanoi.
9
Faculty of Medicine, DuyTan University, Da Nang, Vietnam.

Abstract

Panton-Valentine leukocidin (PVL) is common in African Staphylococcus aureus and can be associated with skin and soft tissue infection. PVL-positive S. aureus colonization is associated with a variant of complement receptor 5a, the cellular target of the lukS PVL subunit.

KEYWORDS:

Staphylococcus aureus ; Panton-Valentine leukocidin; complement C5a; polymorphism; receptor

PMID:
30192927
DOI:
10.1093/cid/ciy666

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