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Semin Cutan Med Surg. 2018 Jun;37(3S):S60-S62. doi: 10.12788/j.sder.2018.024.

Current Concepts in Acne Pathogenesis: Pathways to Inflammation.

Author information

1
Adjunct Professor Schulich School of Medicine and Dentistry Western University Windsor, Ontario, Canada.
2
Director of Dermatology Clinical Research Division Head of Dermatology Henry Ford Hospital Detroit, Michigan.
3
Chair, Department of Dermatology Director of The Skin of Color Center Mount Sinai St. Luke's and Mount Sinai West Associate Professor of Dermatology Icahn School of Medicine at Mount Sinai New York, New York.
4
Clinical Associate Professor of Dermatology University of Alabama at Birmingham Dermatology and Skin Care Center of Birmingham Birmingham, Alabama.

Abstract

Acne is a disease of pilosebaceous inflammation. Pivotal in pathogenesis are the roles of hormones (insulin, insulin-like growth factor-1, androgens), Propionibacterium acnes, lipogenesis, and a proinflammatory lipid profile. Innate immune responses are induced through interaction with toll-like receptors and inflammasome activation initially and subsequently through adaptive immune activation. These insights into pathogenic inflammatory pathways can translate into novel therapeutic approaches for acne. Semin Cutan Med Surg 37(supp3):S60-S62 ©2018 published by Frontline Medical Communication.

KEYWORDS:

Acne; P acnes phylotypes; caspase-1; inflammasome; nitric oxide; pathophysiology; toll-like receptor

PMID:
30192343
DOI:
10.12788/j.sder.2018.024

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