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J Cell Physiol. 2019 Mar;234(3):2317-2328. doi: 10.1002/jcp.27229. Epub 2018 Sep 7.

Potential therapeutic effects of curcumin in gastric cancer.

Author information

1
Deputy of Research and Technology, Hamadan University of Medical Sciences, Hamadan, Iran.
2
Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Irantab.
4
Sabinsa Corporation, East Windsor, New Jersey.
5
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
7
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Despite recent advancements in understanding of the biology of gastric cancer, treatment of patients with advanced gastric cancer remains a major problem. Among different type of phytochemicals, curcumin, a welltable -known phytochemical, has been shown to be a promising cancer chemopreventive agent. Pharmacokinetics, safety, and efficacy of curcumin have been evaluated in several clinical trials against numerous diseases, and for the treatment of human cancer. In the present review, we have collected in vitro and in vivo investigations and studied the chemosensitizing and anticancer effects of curcumin against the gastric cancer cells. In summary, curcumin has been found to have efficient chemosensitizing effect and also inhibits viability, proliferation, and migration of gastric cancer cells mainly via cell cycle arrest and induction of apoptosis by both mitochondrial-dependent and -independent pathways.

KEYWORDS:

apoptosis; chemosensitization; curcumin; gastric cancer; phytochemical

PMID:
30191991
DOI:
10.1002/jcp.27229

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