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Clin Nutr. 2018 Aug 25. pii: S0261-5614(18)32384-7. doi: 10.1016/j.clnu.2018.08.013. [Epub ahead of print]

Extra-skeletal impact of vitamin D supplementation protocol in an adult population with cystic fibrosis.

Author information

1
Institut de Recherches Cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, H3T 1A8, Canada.
2
Department of Medecine, Université de Montréal, Montréal, Québec, H3T 1J4, Canada.
3
Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada.
4
Department of Medecine, Université de Montréal, Montréal, Québec, H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada.
5
Institut de Recherches Cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada. Electronic address: remi.rabasa-lhoret@ircm.qc.ca.
6
Institut de Recherches Cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada.

Abstract

BACKGROUND:

Due to lack of vitamin D absorption in patients with cystic fibrosis (CF), vitamin D supplementation becomes necessary. Our aim was to study the association between serum vitamin D levels and key clinical factors, such as nutritional status, pulmonary function and pulmonary exacerbations (PEx) frequency, in an adult CF population.

METHODS:

Prospective analysis of a published vitamin D (VitD3) supplementation protocol (N = 200 adult patients) over a follow-up period of 5 years. Data were collected from the medical files before (baseline) and after (follow-up) the implementation of the VitD3 supplementation protocol, between 2009 and 2014. Serum samples to measure vitamin D were also collected at baseline and follow-up.

RESULTS:

A positive relationship between serum vitamin D and lung function was observed at baseline (R = 0.158, P = 0.027), but it disappeared at follow-up (P = 0.454). There was no association between serum vitamin D levels and body mass index. At follow-up, patients with significantly higher serum vitamin D levels were women, older in age, had CF-related diabetes or had a history of recurring PEx.

CONCLUSION:

No direct link was observed between heightened serum vitamin D and lung function or BMI in an adult CF population. We suggest that better compliance to treatments and closer follow-up from health professionals could partially explain why such patients reached higher vitamin D serum levels.

KEYWORDS:

CF-related diabetes; Cystic fibrosis; Nutritional status; Pulmonary function; Vitamin D

PMID:
30190118
DOI:
10.1016/j.clnu.2018.08.013

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