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Semin Reprod Med. 2018 Jan;36(1):28-34. doi: 10.1055/s-0038-1667312. Epub 2018 Sep 6.

Large-Scale Evidence-Based Guideline Development Engaging the International PCOS Community.

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National Health and Medical Research Council, Centre for Research Excellence in PCOS, Monash University, Melbourne, Australia.
Monash Centre for Health Research and Implementation, Monash Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
University of New South Wales, Kensington, Sydney, Australia.
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands.


The evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS) integrates the best available evidence with international, multidisciplinary clinical expertise and consumer preferences to provide health professionals, consumers, and policy makers with high-quality, comprehensive guidance about diagnosing and managing PCOS. Here, we outline the rigorous and systematic process, defined a priori and documented to be reproducible, to minimize bias and maintain transparency, in alignment with the Appraisal of Guidelines for Research and Evaluation (AGREE II) criteria and incorporating the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework that render this PCOS evidence-based guideline credible, trustworthy, reliable, and useable.

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