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Scand J Gastroenterol. 2018 Sep;53(9):1027-1030. doi: 10.1080/00365521.2018.1500638. Epub 2018 Sep 6.

Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort.

Author information

1
a Department of Medicine , Zealand University Hospital , Køge , Denmark.
2
b Department of Clinical Microbiology , Hvidovre University Hospital , Hvidovre , Denmark.
3
c Department of Clinical Medicine , University of Copenhagen , ‎ Copenhagen ‎, Denmark.

Abstract

OBJECTIVES:

Use of antibiotics affects the composition of the gut microbiome. The microbiome is thought to play a role in development of irritable bowel syndrome (IBS), but antibiotics as a possible risk factor for IBS has not been clarified. We aimed to explore if antibiotics is a risk factor for IBS by investigating use of antibiotics and development of IBS in a cohort from the Danish background population.

MATERIALS AND METHODS:

An internet-based web panel representative of the Danish background population was invited to participate in a survey regarding the epidemiology of IBS in 2010, 2011 and 2013. A questionnaire based on the Rome III criteria for IBS were answered at all three occasions. In 2013, a question regarding use of antibiotics in the past year was included.

RESULTS:

In 2013, use of antibiotics was reported by 22.4% (624/2781) of the population. A higher proportion of individuals with IBS reported use of antibiotics compared with asymptomatic controls [29.0% (155/534) vs. 17.9% (212/1,184), p < .01]. For asymptomatic respondents in 2010 and 2011 (n = 1004), the relative risk of IBS in 2013 related with use of antibiotics was 1.9 [95% confidence interval (CI): 1.1-3.1]. Adjusting for sex by logistic regression, development of IBS was predicted by use of antibiotics with an odds ratio of 1.8 (95% CI: 1.0-3.2).

CONCLUSIONS:

Antibiotics is a risk factor for IBS in asymptomatic individuals. Possible mechanisms should be investigated in future studies.

KEYWORDS:

Anti-bacterial agents; abdominal pain; functional bowel disorders; microbiome; microbiota

PMID:
30189148
DOI:
10.1080/00365521.2018.1500638
[Indexed for MEDLINE]

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