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Nanomedicine (Lond). 2018 Aug;13(16):1985-1998. doi: 10.2217/nnm-2018-0135. Epub 2018 Sep 6.

Active natural oil-based nanoemulsion containing tacrolimus for synergistic antipsoriatic efficacy.

Author information

1
Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education & Research, Sector 67 SAS Nagar, Punjab - 160 062, India.

Abstract

AIM:

The current study is emphasized on development of a nanoemulsion system that simultaneously delivers two antipsoriatic agents viz. Tacrolimus and Kalonji oil (functional excepient) topically.

MATERIALS & METHODS:

A nanoemulsion was characterized for quality attributes; a nanoemulsion gel was evaluated for spreadability, viscosity, dermal bioavailability, and in vitro efficacy in A-431 cell line, and so forth. In vivo performance was evaluated on psoriasis model in BALB/c mice.

RESULTS:

Nanoemulsion depicted droplet size: 93.37 ± 2.58 nm with PDI (Polydispersity Index) 0.330 ± 0.025. The nanoemulsion gel exhibited desirable spreadability with sustained release pattern (biphasic). Dermal bioavailability enhancement (4.33-fold) accompanied significant in vitro results. A significant reduction in serum cytokines and improvement in psoriatic condition was achieved in vivo, indicating formulation efficacy compared with marketed formulation (Tacroz Forte, Glenmark Pharmaceuticals Ltd, Maharashtra, India).

CONCLUSION:

Nanoemulsion gel thus provides an effective alternative for psoriasis treatment.

KEYWORDS:

Kalonji oil; gel; nanoemulsion; psoriasis; tacrolimus; topical delivery

PMID:
30188761
DOI:
10.2217/nnm-2018-0135
[Indexed for MEDLINE]

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