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Nature. 2018 Sep;561(7721):45-56. doi: 10.1038/s41586-018-0457-8. Epub 2018 Sep 5.

Facing up to the global challenges of ageing.

Author information

1
Max Planck Institute for Biology of Ageing, Cologne, Germany. linda.partridge@age.mpg.de.
2
Institute of Healthy Ageing, and Department of Genetics, Evolution and Environment, UCL, London, UK. linda.partridge@age.mpg.de.
3
Max Planck Institute for Biology of Ageing, Cologne, Germany.
4
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
5
Max Planck Institute for Biology of Ageing, Cologne, Germany. p.slagboom@lumc.nl.
6
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. p.slagboom@lumc.nl.

Abstract

Longer human lives have led to a global burden of late-life disease. However, some olderĀ people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals and drugs can all improve late-life health in animals. Application to humans will require better biomarkers of disease risk and responses to interventions, closer alignment of work in animals and humans, and increased use of electronic health records, biobank resources and cohort studies.

PMID:
30185958
DOI:
10.1038/s41586-018-0457-8
[Indexed for MEDLINE]

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