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Circ J. 2018 Sep 4. doi: 10.1253/circj.CJ-18-0871. [Epub ahead of print]

Clonal Hematopoiesis and Its Impact on Cardiovascular Disease.

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Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine.


A number of recent epidemiological studies have associated the clonal expansion of hematopoietic cells, a process referred to as clonal hematopoiesis, with increased mortality. Clonal hematopoiesis increases the risk of hematological cancer, but this overall risk cannot account for the increase in mortality in the general population. Surprisingly, these mutations have also been associated with higher rates of cardiovascular disease, suggesting a previously unrecognized link between somatic mutations in hematopoietic cells and chronic disease. Here, we review recent epidemiological and experimental studies on clonal hematopoiesis that relate to cardiovascular disease.


Atherosclerosis; Clonal hematopoiesis; Heart failure; Hematopoietic stem cells

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