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Org Biomol Chem. 2018 Sep 19;16(36):6655-6658. doi: 10.1039/c8ob01853g.

Copper-catalyzed C-N bond formation with imidazo[1,2-a]pyridines.

Author information

1
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, P. R. China. sunk468@nenu.edu.cn.

Abstract

An efficient Cu-catalyzed method for direct C-N bond formation on the C-3 position of imidazo[1,2-a]pyridines is reported. The robust copper catalyst tolerated a wide range of functional groups and set the stage for the synthesis of diversely decorated imidazo[1,2-a]pyridines. Preliminary experimental results show that the reaction mechanism is consistent with C-3 radical functionalization.

PMID:
30183799
DOI:
10.1039/c8ob01853g

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