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Int J Cancer. 2018 Sep 5. doi: 10.1002/ijc.31846. [Epub ahead of print]

Molecular and health effects in the upper respiratory tract associated with tobacco smoking other than cigarettes.

Author information

1
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
2
Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland.
3
International Head & Neck Scientific Group, Padua, Italy.
4
Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
5
Department of Otolaryngology, Hospital Universitario Central de Asturias, IUOPA, University of Oviedo, CIBERONC, Oviedo, Spain.
6
Department of Otolaryngology, University of Udine School of Medicine, Udine, Italy.
7
Department of Surgery, University of Arizona College of Medicine, Phoenix, AZ.
8
Coordinator of the International Head & Neck Scientific Group, Padua, Italy.

Abstract

The objective of the review was to compare molecular and health effects of tobacco smoking using cigars, cigarillos, pipe and water pipe in relation to the effects of cigarette smoking. In this review we will focus on the upper respiratory tract. Mechanisms of interaction of tobacco smoke constituents after products other than cigarettes are similar to these associated with cigarette smoking. Carcinogenic activity was demonstrated for any type of tobacco smoking, although the risk of developing head and neck squamous cell carcinoma (HNSCC) remains lower in users of cigars, traditional pipe and water pipe as compared to cigarette smoking. Nevertheless, there is no way of safe tobacco smoking.

KEYWORDS:

cigars; head and neck squamous cell carcinoma; tobacco smoke; toxicity; water pipe

PMID:
30183075
DOI:
10.1002/ijc.31846

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