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Curr Med Chem. 2018 Sep 3. doi: 10.2174/0929867325666180904115633. [Epub ahead of print]

Close interplay of nitro-oxidative stress, advanced glycation end products and inflammation in inflammatory bowel diseases.

Author information

1
Faculdade de Nutrição/Universidade Federal de Alagoas (FANUT/UFAL), Campus A. C. Simões, Avenida Lourival Melo Mota, s/n, Tabuleiro dos Martins, 57072-970 Maceió, AL. Brazil.
2
Instituto de Química e Biotecnologia (IQB), Universidade Federal de Alagoas (UFAL), 57072-970 Maceió, AL. Brazil.
3
Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Universidade Federal de Alagoas (UFAL), 57072-970 Maceió, AL. Brazil.

Abstract

BACKGROUND:

Inflammatory bowel disease (IBD) exhibits no defined aetiology. However, such factors as genetic and nitro-oxidative stress are associated with chronic inflammation and IBD progression to colorectal cancer (CRC). The present review discusses the association of nitro-oxidative stress, inflammation and advanced glycation end products (AGE) and its corresponding receptor (RAGE) in IBD and examines the connection between these factors and nuclear factors, such as nuclear factor kappa B (NF- κB), factor-erythroid 2-related factor-2 (Nrf2), and p53 mutant (p53M).

METHODS:

We searched the PubMed, ScienceDirect and Web of Science databases using a combination of the following terms: IBD, CRC, oxidative stress, inflammation, NF-κB, Nrf2, p53M, AGE and RAGE.

RESULTS:

Oxidative stress and inflammation activated two cellular pathways, the nuclear expression of pro-inflammatory, pro-oxidant and pro-oncogenic genes based on NF-κB and p53M, which is associated with NF-κB activation, deoxyribonucleic acid (DNA) damage and the expression of pro-oncogenic genes. Nrf2 stimulates the nuclear expression of enzymatic and non-enzymatic antioxidant systems and anti-inflammatory genes, and is inhibited by chronic oxidative stress, NF-κB and p53M. AGE/RAGE are involved in inflammation progression because RAGE polymorphisms and increased RAGE levels are found in IBD patients. Alterations of these pathways in combination with oxidative damage are responsible for IBD symptoms and the progression to CRC.

CONCLUSIONS:

IBD is an inflammatory and nitro-oxidative stress-based bowel disease. Achieving a molecular understanding.

KEYWORDS:

colorectal cancer; factor-erythroid 2-related factor-2; lipopolysaccharides; nuclear factor kappa B; p53 mutant

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