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Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Aug 1;36(4):398-403. doi: 10.7518/hxkq.2018.04.010.

[Stromal cell-derived factor-1 inducing metastasis squamous cell carcinoma of head and neck induced via integrin ανβ3-CXC chemokine receptor 4/7 biological axis].

[Article in Chinese; Abstract available in Chinese from the publisher]

Author information

1
Dept. of Head Neck and Thyroid, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008, China.
2
Dept. of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Abstract

in English, Chinese

OBJECTIVE:

To observe the influence of LM609/AMD3100/CCX754 on chemotactic capability, cytoskeleton, and expression of integrin ανβ3 protein of squamous cell carcinoma of head and neck (SCCHN) cell line PCI-13 induced by stromal cell-derived factor-1 (SDF-1) in vitro.

METHODS:

Migration assays, flow cytometry and immunofluorescence were used to observe the effects of SDF-1, LM609, AMD3100 and CCX754 on the migration, cytoskeleton and the expression of integrin ανβ3 protein in PCI-13 cell lines.

RESULTS:

SDF-1 favored PCI-13 cell migration, pseudopod formation, and activities of integrin ανβ3 phosphorylation. LM609, AMD3100, and CCX754 blocked all these effects.

CONCLUSIONS:

SDF-1 can induce metastatic SCCHN by integrin ανβ3-CXC chemokine receptor (CXCR) 4/CXCR7 axi. LM609, AMD3100, and CCX754 and can reduce the regulation of SDF-1 on SCCHN activity.

KEYWORDS:

CXC chemokine receptor; squamous cell carcinoma of head and neck; stromal cell-derived factor-1

PMID:
30182568
DOI:
10.7518/hxkq.2018.04.010
[Indexed for MEDLINE]
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