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Acta Psychiatr Scand. 2019 Jan;139(1):68-77. doi: 10.1111/acps.12957. Epub 2018 Sep 4.

New drug candidates for depression - a nationwide population-based study.

Author information

1
Copenhagen Affective Disorder reaserch Center (CADIC), Psychiatric Center Copenhagen, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
2
Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
3
School of Medicine, Deakin University, Geelong, Vic, Australia.
4
Orygen, The National Centre of Excellence in Youth Mental Health, the Department of Psychiatry, and the Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Vic, Australia.

Abstract

OBJECTIVE:

To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers.

METHODS:

All persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in-patient or out-patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants.

RESULTS:

A total of 1 576 253 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015. Continued use of low-dose aspirin, statins, allopurinol and angiotensin agents was associated with a decreased rate of incident depression according to both outcome measures. Continued uses of non-aspirin NSAIDs as well as high-dose aspirin were associated with an increased rate of incident depression.

CONCLUSION:

The findings support the potential of agents acting on inflammation and the stress response system in depression as well as the potential of population-based registers to systematically identify drugs with repurposing potential.

KEYWORDS:

NSAID; allopurinol; angiotensin; antidepressants; aspirin; depressive disorder; drug repurposing; inflammation; statins; stress

PMID:
30182363
DOI:
10.1111/acps.12957

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