Format

Send to

Choose Destination
Cancers (Basel). 2018 Sep 4;10(9). pii: E306. doi: 10.3390/cancers10090306.

Targeting Raf Kinase Inhibitory Protein Regulation and Function.

Author information

1
Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA. aeyesilkanal@gmail.com.
2
Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA. aeyesilkanal@gmail.com.
3
Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA. m-rosner@uchicago.edu.
4
Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA. m-rosner@uchicago.edu.

Abstract

Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis.

KEYWORDS:

RKIP; kinase; metastasis; signaling; suppressor; therapy

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center