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Biosystems. 2018 Nov;173:181-190. doi: 10.1016/j.biosystems.2018.08.006. Epub 2018 Sep 1.

Nonlinear calcium ion waves along actin filaments control active hair-bundle motility.

Author information

1
Department of Physics, University of Alberta, Edmonton, Alberta, Canada; Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada; Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy.
2
University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia.
3
University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia. Electronic address: dalsek@uns.ac.rs.
4
University of Belgrade, Institute of Nuclear Sciences Vinca, Belgrade, Serbia.

Abstract

Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair-bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force-generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair-bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear.

KEYWORDS:

Actin filament; Calcium ion dynamics; Hair cells; Myosin motor; Nonlinear model

[Indexed for MEDLINE]

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